Is Piperonyl Acetate safe in cosmetics?
Piperonyl Acetate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Piperonyl Acetate
Also known as: 1,3-Benzodioxole-5-methanol, 5-acetate, 4-19-00-00736, BRN 0384173, EINECS 206-312-5, FEMA No. 2912 (+6 more)
INCI: PIPERONYL ACETATE
Piperonyl Acetate (CAS 326-61-4) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 326-61-4 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
1,3-benzodioxol-5-ylmethyl acetate
InChIKey
PFWYHTORQZAGCA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA; subject to general cosmetic safety requirements
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Piperonyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
3100 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [183] Kligman AM (1973): Report to RIFM, 31 October, unpublished.
HRIPT Human Patch Test Studies
4 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 104 | 0 | 4724 | 4724 | non-sensitizer |
| HMT | - | 0 | 5184 | - | - |
| HRIPT | - | 0 | 3100.01 | - | - |
| HRIPT | - | 0 | 4724 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
894
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HELIOTROPIN ACETATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PIPERONYL ACETATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HELIOTROPYL ACETATE | 2001 | No safety concern at current levels of intake when used as a flavouring agent | TRS 909-JECFA 57/84 | FAS 48-JECFA 57/273
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Piperonyl Acetate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
1,3-Benzodioxole-5-methanol, 5-acetate
4-19-00-00736
BRN 0384173
EINECS 206-312-5
FEMA No. 2912
Heliotropin acetate
Heliotropyl acetate
3,4-Methylenedioxybenzyl acetate
NSC 406725
Piperonyl alcohol, acetate
UNII-090XZ4C7VN
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1366925
Frequently Asked Questions
Is Piperonyl Acetate allowed in the EU?
Piperonyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Piperonyl Acetate do in cosmetics?
Piperonyl Acetate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 326-61-4.
Is Piperonyl Acetate used outside cosmetics?
Piperonyl Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Piperonyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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