Poloxamine 1101

INCI: POLOXAMINE 1101

CAS Number
11111-34-5
Function
Surfactant – Cleansing; Surfactant – Emulsifying; Fragrance Functional
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No specific FDA monograph; no CIR safety assessment published

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Residual 1,4-dioxane and ethylene oxide/propylene oxide impurities present; low ethylene oxide content (approximately 10%) confers more lipophilic character; absence of CIR/SCCS monograph requires CPSR assessor to rely on read-across data and supplier toxicology information.

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Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance

Frequently Asked Questions

Is Poloxamine 1101 safe in cosmetics?

Residual 1,4-dioxane and ethylene oxide/propylene oxide impurities present; low ethylene oxide content (approximately 10%) confers more lipophilic character; absence of CIR/SCCS monograph requires CPSR assessor to rely on read-across data and supplier toxicology information. The EU classifies Poloxamine 1101 as "permitted". Safety rating: MODERATE.

Is Poloxamine 1101 allowed in the EU?

Poloxamine 1101 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Poloxamine 1101 do in cosmetics?

Poloxamine 1101 functions as: Surfactant – Cleansing; Surfactant – Emulsifying; Fragrance Functional. It is classified as a cosmetic ingredient in our database. CAS number: 11111-34-5.

What is the Margin of Safety for Poloxamine 1101?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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