Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Polyaminopropyl Biguanide based on clinical patch test studies and IFRA standards.
Source: ESSCA 2019/20; IVDK; FDA
Expert Verdict
Safe at ≤0.1% in non-spray cosmetics (Annex V/28). Prohibited in spray/aerosolized products due to inhalation hazard (H330). CMR Cat. 2 classification. MoS adequate at 0.1%. Cationic polymer; verify anionic compatibility.
Regulatory Flags
Frequently Asked Questions
Is Polyaminopropyl Biguanide safe in cosmetics?
Safe at ≤0.1% in non-spray cosmetics (Annex V/28). Prohibited in spray/aerosolized products due to inhalation hazard (H330). CMR Cat. 2 classification. MoS adequate at 0.1%. Cationic polymer; verify anionic compatibility. The EU classifies Polyaminopropyl Biguanide as "restricted". Safety rating: MODERATE.
Is Polyaminopropyl Biguanide allowed in the EU?
Polyaminopropyl Biguanide EU regulatory status: restricted. Maximum allowed concentration: 0.1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Polyaminopropyl Biguanide do in cosmetics?
Polyaminopropyl Biguanide functions as: Preservative (Broad-Spectrum Antimicrobial). It is classified as a Preservative in our database. CAS number: 32289-58-0.
What is the Margin of Safety for Polyaminopropyl Biguanide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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