Polybutylene Glycol/MDI Copolymer

INCI: POLYBUTYLENE GLYCOL/MDI COPOLYMER

CAS Number
Not publicly assigned
Function
Film forming
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes PCPC listed; no FDA restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

MDI (methylene diphenyl diisocyanate) is classified as a respiratory sensitizer (EU Harmonised Classification: Resp. Sens. 1, H334) and skin sensitizer. Residual unreacted MDI must be verified at <0.1% per REACH. Supplier CoA for free isocyanate content is mandatory. Not suitable for spray/aerosol applications without confirming zero free NCO groups.

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Concern Level: High

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Polybutylene Glycol/MDI Copolymer safe in cosmetics?

MDI (methylene diphenyl diisocyanate) is classified as a respiratory sensitizer (EU Harmonised Classification: Resp. Sens. 1, H334) and skin sensitizer. Residual unreacted MDI must be verified at <0.1% per REACH. Supplier CoA for free isocyanate content is mandatory. Not suitable for spray/aerosol applications without confirming zero free NCO groups. The EU classifies Polybutylene Glycol/MDI Copolymer as "permitted". Safety rating: MODERATE.

Is Polybutylene Glycol/MDI Copolymer allowed in the EU?

Polybutylene Glycol/MDI Copolymer EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polybutylene Glycol/MDI Copolymer do in cosmetics?

Polybutylene Glycol/MDI Copolymer functions as: Film forming. It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned.

What is the Margin of Safety for Polybutylene Glycol/MDI Copolymer?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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