Regulatory Status
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Safety Data
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Expert Verdict
Oxidative quinone formation on skin contact. Monomer (5,6-DHI) max 5% in formulation per SCCNFP dossier. Ensure polymer purity and confirm residual monomer levels. Potential cross-reactivity with PPD-sensitized individuals.
Regulatory Flags
Frequently Asked Questions
Is Polydihydroxyindole safe in cosmetics?
Oxidative quinone formation on skin contact. Monomer (5,6-DHI) max 5% in formulation per SCCNFP dossier. Ensure polymer purity and confirm residual monomer levels. Potential cross-reactivity with PPD-sensitized individuals. The EU classifies Polydihydroxyindole as "permitted". Safety rating: MODERATE.
Is Polydihydroxyindole allowed in the EU?
Polydihydroxyindole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Polydihydroxyindole do in cosmetics?
Polydihydroxyindole functions as: Hair dyeing (melanin-pathway precursor polymer). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned in CosIng.
What is the Margin of Safety for Polydihydroxyindole?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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