Polygamma-Glutamic Acid

INCI: POLYGLUTAMIC ACID

CAS Number
25513-46-6 / 84960-48-5
Function
Skin conditioning; humectant; film forming
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No CIR final report; generally permitted; growing commercial use as moisturizing agent

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Fermentation-derived ingredient requiring microbial contamination controls; endotoxin levels must be acceptable; molecular weight grade affects performance and absorption.

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Concern Level: Low

Frequently Asked Questions

Is Polygamma-Glutamic Acid safe in cosmetics?

Fermentation-derived ingredient requiring microbial contamination controls; endotoxin levels must be acceptable; molecular weight grade affects performance and absorption. The EU classifies Polygamma-Glutamic Acid as "permitted". Safety rating: GOOD.

Is Polygamma-Glutamic Acid allowed in the EU?

Polygamma-Glutamic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Polygamma-Glutamic Acid do in cosmetics?

Polygamma-Glutamic Acid functions as: Skin conditioning; humectant; film forming. It is classified as a cosmetic ingredient in our database. CAS number: 25513-46-6 / 84960-48-5.

What is the Margin of Safety for Polygamma-Glutamic Acid?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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