Is Polygamma-Glutamic Acid safe in cosmetics?
Polygamma-Glutamic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Polygamma-Glutamic Acid
INCI: POLYGLUTAMIC ACID
Polygamma-Glutamic Acid (CAS 25513-46-6 / 84960-48-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning; humectant; film forming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 25513-46-6 / 84960-48-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; humectant; film forming
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No CIR final report; generally permitted; growing commercial use as moisturizing agent
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Polygamma-Glutamic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
9 property records from structured ingredient metadata.
acne
{"cas_number": "25513-46-6", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_aging
{"anti_aging_claim": "hydration-plumping, barrier-repair", "mechanism_of_action": "Humectant, water binding, barrier support", "target_skin_layer": "stratum corneum, epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "12-20", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal"…
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "2.0", "typical_concentration_pct": "1.0", "product_type": "Moisturizer", "function_at_concentration": "Super hydrator", "source": "Supplier TDS"}
fermentation
{"cas_number": "varies", "ingredient_class": "biofermented_acid", "production_organism": "bacteria", "fermentation_type": "aerobic", "substrate_feedstock": "glucose, sucrose", "bioactive_compounds_produced": "polyglutamic", "mechanism_of_action_skin": "exfoliation, hydration, pH regulation", "skin_benefit_primary": "moisturizing", "skin_benefit_secondary": "brightening, anti_aging", "clinical_evid…
interactions
{"ingredient_2": "Hyaluronic Acid", "interaction_type": "synergistic", "severity": "beneficial", "effect": "Enhanced water-binding capacity, superior to HA alone", "recommendation": "Emerging combination for intense hydration", "data_source": "Formulation science literature, dermatological research, cosmetic chemistry best practices", "last_updated": "2026-03-05"}
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Safe; holds more water than HA", "source": "dermatology literature"}
sensory
{"silky": "gel-like", "smooth, glides easily": "slippery, hydrating", "dry-touch, non-greasy": "hydrated, plump", "instant": "moderate", "low": "high", "w/o": "o/w", "very-high": "moderate", "no": "no", "yes": "no", "1.40": "1.50", "transparent": "transparent", "colorless": "colorless", "excellent": "fair", "light": "light", "synthetic": "biotechnology"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "recommended", "sensitive_skin": "recommended", "combination_skin": "acceptable", "normal_skin": "recommended", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "recommended", "dehydrated": "recommended", "skin_benefit_primary": "hydrating", "skin_benefit_secondary": "film-forming…
Expert Verdict
Expert safety assessment and concern-level summary for Polygamma-Glutamic Acid.
Frequently Asked Questions
Is Polygamma-Glutamic Acid allowed in the EU?
Polygamma-Glutamic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Polygamma-Glutamic Acid do in cosmetics?
Polygamma-Glutamic Acid functions as: Skin conditioning; humectant; film forming. It is classified as a cosmetic ingredient in our database. CAS number: 25513-46-6 / 84960-48-5.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Antioxidant
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Solvent
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Light Stabilizer
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