Gamma-Polyglutamic Acid (γ-PGA)

INCI: POLYGLUTAMIC ACID

CAS Number
25513-46-6 (polyglutamic acid); 208106-41-6 (sodium salt)
Function
Skin Conditioning, Humectant/Moisturizing
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; no FDA restriction; CIR has not published a standalone monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Minimal concerns; biodegradable, non-toxic, non-irritating; verify absence of fermentation residues in certificate of analysis

⚠️
Concern Level: Low

Frequently Asked Questions

Is Gamma-Polyglutamic Acid (γ-PGA) safe in cosmetics?

Minimal concerns; biodegradable, non-toxic, non-irritating; verify absence of fermentation residues in certificate of analysis The EU classifies Gamma-Polyglutamic Acid (γ-PGA) as "permitted". Safety rating: EXCELLENT.

Is Gamma-Polyglutamic Acid (γ-PGA) allowed in the EU?

Gamma-Polyglutamic Acid (γ-PGA) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Gamma-Polyglutamic Acid (γ-PGA) do in cosmetics?

Gamma-Polyglutamic Acid (γ-PGA) functions as: Skin Conditioning, Humectant/Moisturizing. It is classified as a cosmetic ingredient in our database. CAS number: 25513-46-6 (polyglutamic acid); 208106-41-6 (sodium salt).

What is the Margin of Safety for Gamma-Polyglutamic Acid (γ-PGA)?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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