Polyglyceryl-4 Polyricinoleate
INCI: POLYGLYCERYL-4 POLYRICINOLEATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Polyglyceryl-4 Polyricinoleate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 845 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 167 2105 | 1992 | rat | inhalation | REACH |
| NOAEL | >=8000 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 50000 ppm | oral | rat | oral | REACH |
| LOAEL | 5 other | oral | rat | oral | REACH |
| NOAEL | 10000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
JECFA food-grade specs: lead ≤ 2 mg/kg; polyglycerol moiety ≥ 70% di-/tri-/tetraglycerols, ≤ 10% ≥ heptaglycerol. Formulate to be non-irritating.
Frequently Asked Questions
Is Polyglyceryl-4 Polyricinoleate safe in cosmetics?
JECFA food-grade specs: lead ≤ 2 mg/kg; polyglycerol moiety ≥ 70% di-/tri-/tetraglycerols, ≤ 10% ≥ heptaglycerol. Formulate to be non-irritating. The EU classifies Polyglyceryl-4 Polyricinoleate as "permitted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.
Is Polyglyceryl-4 Polyricinoleate allowed in the EU?
Polyglyceryl-4 Polyricinoleate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Polyglyceryl-4 Polyricinoleate do in cosmetics?
Polyglyceryl-4 Polyricinoleate functions as: Emulsifying agent; skin conditioning; viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 29894-35-7.
What is the Margin of Safety for Polyglyceryl-4 Polyricinoleate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Polyglyceryl-4 Polyricinoleate?
The NOAEL (No Observed Adverse Effect Level) for Polyglyceryl-4 Polyricinoleate is 845 mg/kg bw/day based on a oral study via oral route in rat. A total of 6 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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