NOAEL Studies UV Filter / Sunscreen

Polysilicone-15 NOAEL Studies

INCI: POLYSILICONE-15

CAS: 207574-74-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB LOAEL 60 mg/kg bw/day rat oral 90 day Subchronic SCCS; Bremer K.D. Toxicological Laboratories, F. Hoffman-La Roche Ltd., CH-4070, Basel, Switzerland
SCCS Opinion 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =1000 mg/kg bw/day - - Chronic genotoxicity p.15
SCCS Opinion NOAEL =0.6 mg/kg bw/d rat oral 90 day dermal absorption p.22
SCCS Opinion NOAEL =1000 mg/kg bw/d rat oral 90 day dermal absorption p.22
Regulatory source 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source dermal absorption =0.6 mg/kg bw/d rat oral 90 day dermal absorption p.22
Regulatory source dermal absorption =1000 mg/kg bw/d rat oral 90 day dermal absorption p.22
Regulatory source genotoxicity 1000 mg/kg bw/day - - Chronic genotoxicity p.15
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier F8DRP5BB29 UNII - - - polymer -