Is Polysilicone-15 safe in cosmetics?
Polysilicone-15 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Polysilicone-15
INCI: POLYSILICONE-15
Polysilicone-15 (CAS 207574-74-1) is a cosmetic uv filter / sunscreen functioning as UVB filter (280-320 nm, peak 312 nm). Reported NOAEL =0.6 mg/kg bw/d in rat (SCCS Opinion); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 207574-74-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Polysilicone-15 is classified GHS Danger (H330, H413) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
UVB filter (280-320 nm, peak 312 nm)
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Polysilicone-15.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Polysilicone-15. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.6 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.6 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.6 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =0.6 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/day | - | - | genotoxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/day | - | - | genotoxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/day | - | - | genotoxicity | SCCS Opinion |
| NOAEL | =1000 mg/kg bw/d | oral | rat | dermal absorption | SCCS Opinion |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Polysilicone-15, relevant to systemic exposure and MoS calculations.
Absorption %
0.5-2%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
Variable Da
Log P
7.5
Systemic Absorption
minimal
Topical Bioavailability
0.2-1%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation
Source: SCCS Opinion
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex VI — Permitted UV Filters
Max: 10%
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: UV Filter. Max: 10%.
SA Saudi SFDA (VI - UV Filters)
Max: 0.1.
JPKR Japan/Korea Cosmetics
Japan (Positive (UV Absorber)): max 10.0
BRIN Brazil/India Cosmetics
India: Permitted UV Filter · max 0.1
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_uv_filter | 10 | All cosmetics |
| CN | permitted_uv_filter | 10 | All cosmetics |
| IN | permitted_uv_filter | 10.0 | sunscreen and other cosmetic products |
| BR | permitted_uv_filter | 10 | Sunscreen products |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 2.0% | - | - | SCCS/0024 |
Additional Ingredient Properties
7 property records from structured ingredient metadata.
anti_pollution
{"cas_number": "207574-74-1", "ingredient_class": "blue_light_filter", "primary_mechanism": "film_forming_barrier", "pollution_types_targeted": "UV_B/partial_HEV", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation…
baby_pediatric
{"cas_number": "207574-74-1", "ingredient_class": "sunscreen_baby", "pediatric_safety_rating": "acceptable", "minimum_age_months": "12", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Polymer UV filter", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "S…
dermal_absorption
{"molecular_weight_da": "Variable", "log_p_value": "7.5", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "0.5-2", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "yes", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0.2-1", "safety_margin_factor": "minimal", "source": …
polymer
{"ingredient_class": "film_former/waterproofing_agent", "polymer_type": "silicone_based", "chemical_backbone": "other", "molecular_weight_Da_range": "8000-70000", "ionic_character": "nonionic", "pH_viscosity_sensitivity": "moderate", "salt_tolerance": "moderate", "electrolyte_effect_on_viscosity": "moderate", "temperature_viscosity_sensitivity": "moderate", "film_transparency": "transparent", "fil…
silicone
{"cas_number": "179005-80-6", "silicone_class": "silicone_resin", "molecular_weight_Da": "7200.0", "viscosity_cSt": "solid", "volatility": "non_volatile", "evaporation_rate_relative_to_D5": "0.0001", "refractive_index": "1.4135", "specific_gravity": "1.18", "flash_point_C": "205.0", "surface_tension_mN_m": "24.2", "spreading_coefficient": "2.6", "film_forming_ability": "excellent", "skin_feel": "w…
sunscreen_uv
{"cas_number": "207574-74-1", "uv_filter_type": "organic_UVB", "chemical_class": "other", "absorption_spectrum_nm_range": "290-320", "peak_absorption_wavelength_nm": "312", "molar_extinction_coefficient": "26000", "critical_wavelength_nm": "322", "UVA_PF": "2-3", "SPF_contribution_per_percent": "8.5", "photostability_rating": "photostable", "photodegradation_half_life_hours": ">18", "photostabiliz…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "0", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "yes", "photostable_sunscreen": "yes", "boost_spf_of_others": "no", "antioxidant_under_uv"…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
UV stabilizer
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Polysilicone-15.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Polysilicone-15 by CAS number or substance name.
Studies
12
Lowest NOAEL
0.6
Highest NOAEL
1000
Units vary across source rows: mg/kg bw/d, mg/kg bw/day
SCCS Opinion
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 2.0% | - | - |
Chemical Function
UV stabilizer
Regulatory Lists
Canada; pharmaceutical
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Polysilicone-15 allowed in the EU?
Polysilicone-15 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Polysilicone-15 do in cosmetics?
Polysilicone-15 functions as: UVB filter (280-320 nm, peak 312 nm). It is classified as a UV Filter / Sunscreen in our database. CAS number: 207574-74-1.
What is the NOAEL for Polysilicone-15?
The NOAEL (No Observed Adverse Effect Level) for Polysilicone-15 is =0.6 mg/kg bw/d based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS Opinion.
Is Polysilicone-15 used outside cosmetics?
Polysilicone-15 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Polysilicone-15 have different safety status in cosmetics vs industrial chemicals?
Polysilicone-15 is classified GHS Danger (H330, H413) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Polysilicone-15 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
GLUCOMANNAN
Excellent
Same category
Humectant, viscosity control agent
Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M)
Excellent
Same category
UV filter
Saccharide Isomerate
Excellent
Same category
UV Filter
Sulisobenzone (Benzophenone-4)
Excellent
Same category
UV Filter
Amiloxate
Good
Same category
UV Filter
Amiloxate (Isoamyl p-Methoxycinnamate)
Good
Same category
Antioxidant
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
POLY 1,2-BUTANEDIOL-6 PROPYLENE GLYCOL
Good
Browse nearby
Solvent
POLY METHYL STYRENE ISOPROPANOL KETONE
Good
Browse nearby
Light Stabilizer
POLY(1-4 BUTANEDIOL)-27
Good
Browse nearby
Not Reported
Is Polysilicone-15 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Polysilicone-15 in your formulation.