Potassium Fluorosilicate
INCI: POTASSIUM FLUOROSILICATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Potassium Fluorosilicate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | ca.25 ppm | oral | rat | oral | REACH |
| LOAEL | ca.4 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | ca.100 ppm | oral | rat | oral | REACH |
| LOAEL | ca.50 ppm | oral | mouse | oral | REACH |
| LOAEL | ca.25 ppm | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Restricted in EU to 0.15% maximum concentration due to toxicity from fluorosilicate dissociation. Classified as toxic if swallowed (H301); more acutely toxic than simple fluoride salts. Limited use in US cosmetics; not approved as OTC anticaries active.
Regulatory Flags
Frequently Asked Questions
Is Potassium Fluorosilicate safe in cosmetics?
Restricted in EU to 0.15% maximum concentration due to toxicity from fluorosilicate dissociation. Classified as toxic if swallowed (H301); more acutely toxic than simple fluoride salts. Limited use in US cosmetics; not approved as OTC anticaries active. The EU classifies Potassium Fluorosilicate as "restricted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.
Is Potassium Fluorosilicate allowed in the EU?
Potassium Fluorosilicate EU regulatory status: restricted. Maximum allowed concentration: 0.15%. This is based on EU Regulation 1223/2009 and its amendments.
What does Potassium Fluorosilicate do in cosmetics?
Potassium Fluorosilicate functions as: Antiplaque, oral care. It is classified as a cosmetic ingredient in our database. CAS number: 16871-90-2.
What is the Margin of Safety for Potassium Fluorosilicate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Potassium Fluorosilicate?
The NOAEL (No Observed Adverse Effect Level) for Potassium Fluorosilicate is ca.25 ppm based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.
Is Potassium Fluorosilicate classified as hazardous under GHS?
Potassium Fluorosilicate carries a GHS signal word of "DANGER". Hazard statements: Toxic if swallowed May cause damage to blood and cardiovascular system May cause damage to teeth and bones through prolonged or repeated exposure. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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