Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Potassium Persulfate

INCI: POTASSIUM PERSULFATE

CAS Number

7727-21-1

Function

Oxidizing agent for hair colorants and hair lighteners

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes CIR Panel concluded safe as used in hair colorants and lighteners for brief discontinuous use followed by thorough rinsing; insufficient data for leave-on products and dentifrices

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

low

Sensitization

high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for Potassium Persulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
LOAEL	3000 ppm	oral	rat	oral	REACH
NOAEL	91 mg/kg bw/day	oral	-	oral	REACH
NOAEL	131.5 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	41.1 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	41.1 mg/kg bw/day	oral	-	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects

The substance is irritating to the eyes, skin and respiratory tract. Inhalation of dust may cause asthma-like reactions.

Long-term Exposure Effects

Repeated or prolonged contact with skin may cause dermatitis. Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. May cause a general allergic reaction, such as urticaria or shock.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Expert Verdict

⚠️

Concern Level: High

Regulatory Flags

potential-allergen colorant fda_food_additive

Frequently Asked Questions

Is Potassium Persulfate safe in cosmetics?

Strong sensitizer causing Type I and Type IV reactions; occupational asthma risk in hairdressers and respiratory sensitization concern with powder and aerosol forms; not approved for leave-on products. The EU classifies Potassium Persulfate as "permitted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.

Is Potassium Persulfate allowed in the EU?

Potassium Persulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Potassium Persulfate do in cosmetics?

Potassium Persulfate functions as: Oxidizing agent for hair colorants and hair lighteners. It is classified as a cosmetic ingredient in our database. CAS number: 7727-21-1.

What is the Margin of Safety for Potassium Persulfate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Potassium Persulfate?

The NOAEL (No Observed Adverse Effect Level) for Potassium Persulfate is 3000 ppm based on a oral study via oral route in rat. A total of 5 study endpoints are available. Source: REACH.

Compliance Tools

Check Potassium Persulfate compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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