Is Pregnane safe in cosmetics?
Pregnane has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
MODERATE
Cosmetic Ingredient
Pregnane
Also known as: 17β-Ethyletiocholane
INCI: PREGNANE
Pregnane (CAS 481-26-5) is a cosmetic cosmetic ingredient functioning as Not a standard cosmetic functional ingredient — it is the parent C₂₁ steroid. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
Cross-Vertical Regulatory Divergence
Pregnane is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Not a standard cosmetic functional ingredient — it is the parent C₂₁ steroid backbone for pregnane-derived compounds
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(5S,8S,9S,10S,13R,14S,17S)-17-ethyl-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
InChIKey
JWMFYGXQPXQEEM-NUNROCCHSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not listed in FDA's VCRP or CIR database as a cosmetic ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pregnane.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Pregnane — not a computed safety verdict. See the sourced toxicological data above.
Known Synonyms
17β-Ethyletiocholane
Frequently Asked Questions
Is Pregnane allowed in the EU?
Pregnane EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Pregnane do in cosmetics?
Pregnane functions as: Not a standard cosmetic functional ingredient — it is the parent C₂₁ steroid backbone for pregnane-derived compounds. It is classified as a cosmetic ingredient in our database. CAS number: 481-26-5.
Is Pregnane used outside cosmetics?
Pregnane also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Pregnane have different safety status in cosmetics vs industrial chemicals?
Pregnane is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Compliance Tools
Check Pregnane compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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