1-Nitropropane
INCI: NOT ASSIGNED A COSMETIC INCI (INDUSTRIAL SOLVENT; NOT A COSMETIC INGREDIENT)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 1-Nitropropane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 30 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 48 2284 | 1991 | rat | inhalation | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Do not use in cosmetics. Hepatotoxicity; methemoglobinemia risk; CNS depression; structural analog (2-nitropropane) is a probable carcinogen; no NOAEL established for dermal cosmetic exposure; occupational exposure limits exist (25 ppm TWA)
Frequently Asked Questions
Is 1-Nitropropane safe in cosmetics?
Do not use in cosmetics. Hepatotoxicity; methemoglobinemia risk; CNS depression; structural analog (2-nitropropane) is a probable carcinogen; no NOAEL established for dermal cosmetic exposure; occupational exposure limits exist (25 ppm TWA) The EU classifies 1-Nitropropane as "prohibited". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.
Is 1-Nitropropane allowed in the EU?
1-Nitropropane EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 1-Nitropropane do in cosmetics?
1-Nitropropane functions as: None in cosmetics - industrial solvent/chemical intermediate. It is classified as a cosmetic ingredient in our database. CAS number: 108-03-2.
What is the Margin of Safety for 1-Nitropropane?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for 1-Nitropropane?
The NOAEL (No Observed Adverse Effect Level) for 1-Nitropropane is 30 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
Check 1-Nitropropane compliance across multiple jurisdictions:
Related Ingredients
Is 1-Nitropropane in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 1-Nitropropane in your formulation.