Propylene Glycol Dicaprylate/Dicaprate

INCI: PROPYLENE GLYCOL DICAPRYLATE/DICAPRATE

CAS Number
58748-27-9
Function
Skin conditioning agent, emollient, solvent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes GRAS as food additive under 21 CFR 172.856; no cosmetic restrictions.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

CIR safe as used with robust oral data (NOAEL 1,000 mg/kg/day); documented penetration enhancer requiring caution in co-formulations with actives.

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Concern Level: Low

Regulatory Flags

PENETRATION_ENHANCER

Frequently Asked Questions

Is Propylene Glycol Dicaprylate/Dicaprate safe in cosmetics?

CIR safe as used with robust oral data (NOAEL 1,000 mg/kg/day); documented penetration enhancer requiring caution in co-formulations with actives. The EU classifies Propylene Glycol Dicaprylate/Dicaprate as "permitted". Safety rating: GOOD.

Is Propylene Glycol Dicaprylate/Dicaprate allowed in the EU?

Propylene Glycol Dicaprylate/Dicaprate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Propylene Glycol Dicaprylate/Dicaprate do in cosmetics?

Propylene Glycol Dicaprylate/Dicaprate functions as: Skin conditioning agent, emollient, solvent. It is classified as a cosmetic ingredient in our database. CAS number: 58748-27-9.

What is the Margin of Safety for Propylene Glycol Dicaprylate/Dicaprate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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