Propylene Glycol Dipelargonate

INCI: PROPYLENE GLYCOL DIPELARGONATE

CAS Number
41395-83-9
Function
Skin-conditioning agent (occlusive); viscosity increasing agent (nonaqueous)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR safe as used (1999, reaffirmed 2014); highest reported concentration of use: 60% in perfumes

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Strongest documented penetration enhancer in this group โ€” enhances heparin, thiocolchicoside, caffeine, and methyl nicotinate; low polarity enables deep stratum corneum penetration and lipid bilayer interaction; exercise heightened caution in formulations with actives sensitive to dermal absorption

โš ๏ธ
Concern Level: Moderate

Frequently Asked Questions

Is Propylene Glycol Dipelargonate safe in cosmetics?

Strongest documented penetration enhancer in this group โ€” enhances heparin, thiocolchicoside, caffeine, and methyl nicotinate; low polarity enables deep stratum corneum penetration and lipid bilayer interaction; exercise heightened caution in formulations with actives sensitive to dermal absorption The EU classifies Propylene Glycol Dipelargonate as "permitted". Safety rating: MODERATE.

Is Propylene Glycol Dipelargonate allowed in the EU?

Propylene Glycol Dipelargonate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Propylene Glycol Dipelargonate do in cosmetics?

Propylene Glycol Dipelargonate functions as: Skin-conditioning agent (occlusive); viscosity increasing agent (nonaqueous). It is classified as a cosmetic ingredient in our database. CAS number: 41395-83-9.

What is the Margin of Safety for Propylene Glycol Dipelargonate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Propylene Glycol Dipelargonate in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Propylene Glycol Dipelargonate in your formulation.