Pyridoxine Dipalmitate

INCI: PYRIDOXINE DIPALMITATE [^1_3]

CAS Number
635-38-1 (also listed as 31229-74-0 / 39379-66-3) [^1_1][^1_2]
Function
Skin conditioning, anti-acne, anti-inflammatory, hair conditioning, antistatic [^1_4][^1_2]
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not separately regulated as a drug; permitted in cosmetics; max reported use in leave-on products: 0.005% [^1_4]

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

At very high concentrations, free pyridoxine metabolites can be neurotoxic (oral, chronic); irrelevant at cosmetic use levels. Ensure purity โ€” free palmitic acid levels may affect formulation pH [^1_4][^1_2]

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Concern Level: Moderate

Frequently Asked Questions

Is Pyridoxine Dipalmitate safe in cosmetics?

At very high concentrations, free pyridoxine metabolites can be neurotoxic (oral, chronic); irrelevant at cosmetic use levels. Ensure purity โ€” free palmitic acid levels may affect formulation pH [^1_4][^1_2] The EU classifies Pyridoxine Dipalmitate as "restricted". Safety rating: GOOD.

Is Pyridoxine Dipalmitate allowed in the EU?

Pyridoxine Dipalmitate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pyridoxine Dipalmitate do in cosmetics?

Pyridoxine Dipalmitate functions as: Skin conditioning, anti-acne, anti-inflammatory, hair conditioning, antistatic [^1_4][^1_2]. It is classified as a cosmetic ingredient in our database. CAS number: 635-38-1 (also listed as 31229-74-0 / 39379-66-3) [^1_1][^1_2].

What is the Margin of Safety for Pyridoxine Dipalmitate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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