Pyridoxine Glycyrrhetinate

INCI: PYRIDOXINE GLYCYRRHETINATE [^1_6]

CAS Number
3390-81-6 [^1_6]
Function
Skin conditioning, anti-inflammatory (combines Vitamin B6 + glycyrrhetinic acid moiety) [^1_6][^1_7]
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted in cosmetics under general cosmetic ingredient allowances; no specific FDA monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Glycyrrhetinic acid at high systemic levels can inhibit 11ฮฒ-HSD causing pseudo-aldosteronism; not a realistic concern at topical cosmetic use levels. Monitor concentration carefully [^1_6]

โš ๏ธ
Concern Level: Low

Frequently Asked Questions

Is Pyridoxine Glycyrrhetinate safe in cosmetics?

Glycyrrhetinic acid at high systemic levels can inhibit 11ฮฒ-HSD causing pseudo-aldosteronism; not a realistic concern at topical cosmetic use levels. Monitor concentration carefully [^1_6] The EU classifies Pyridoxine Glycyrrhetinate as "permitted". Safety rating: GOOD.

Is Pyridoxine Glycyrrhetinate allowed in the EU?

Pyridoxine Glycyrrhetinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pyridoxine Glycyrrhetinate do in cosmetics?

Pyridoxine Glycyrrhetinate functions as: Skin conditioning, anti-inflammatory (combines Vitamin B6 + glycyrrhetinic acid moiety) [^1_6][^1_7]. It is classified as a cosmetic ingredient in our database. CAS number: 3390-81-6 [^1_6].

What is the Margin of Safety for Pyridoxine Glycyrrhetinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Pyridoxine Glycyrrhetinate in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Pyridoxine Glycyrrhetinate in your formulation.