Good Cosmetic Ingredient

Pyridoxine Salicylate

INCI: PYRIDOXINE SALICYLATE [^1_12]

CAS Number
Not widely published; CosIng-listed [^1_12]
Function
Skin conditioning; the salicylate moiety adds keratolytic/anti-inflammatory potential [^1_12]
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status restricted
EU Max Conc. 2%
🇺🇸 US Status permitted
US Notes Permitted in cosmetics; salicylic acid is an OTC drug active (anti-acne) in the US — if the product makes drug claims, it triggers OTC monograph requirements

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

EU Annex III restriction on salicylic acid (≤2%, not for use in products for children under 3) likely applies by read-through. In the US, salicylate release could shift the product from cosmetic to OTC drug if anti-acne/keratolytic claims are made. Aspirin-sensitive individuals may react [^1_12]

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Concern Level: Low

Frequently Asked Questions

Is Pyridoxine Salicylate safe in cosmetics?

EU Annex III restriction on salicylic acid (≤2%, not for use in products for children under 3) likely applies by read-through. In the US, salicylate release could shift the product from cosmetic to OTC drug if anti-acne/keratolytic claims are made. Aspirin-sensitive individuals may react [^1_12] The EU classifies Pyridoxine Salicylate as "restricted". Safety rating: GOOD.

Is Pyridoxine Salicylate allowed in the EU?

Pyridoxine Salicylate EU regulatory status: restricted. Maximum allowed concentration: 2%. This is based on EU Regulation 1223/2009 and its amendments.

What does Pyridoxine Salicylate do in cosmetics?

Pyridoxine Salicylate functions as: Skin conditioning; the salicylate moiety adds keratolytic/anti-inflammatory potential [^1_12]. It is classified as a cosmetic ingredient in our database. CAS number: Not widely published; CosIng-listed [^1_12].

What is the Margin of Safety for Pyridoxine Salicylate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Pyridoxine Salicylate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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