Pyridoxine Tripalmitate

INCI: PYRIDOXINE TRIPALMITATE [^1_13]

CAS Number
4372-46-7 (referenced) [^1_13]
Function
Skin conditioning, emollient (tri-ester of pyridoxine with palmitic acid — more lipophilic than dipalmitate) [^1_13]
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted in cosmetics; no specific FDA monograph

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Very large molecular weight limits systemic absorption — generally favorable from a safety standpoint. Less commercially common than dipalmitate; ensure supplier CoA includes purity and residual solvent data [^1_13]

⚠️
Concern Level: Low

Frequently Asked Questions

Is Pyridoxine Tripalmitate safe in cosmetics?

Very large molecular weight limits systemic absorption — generally favorable from a safety standpoint. Less commercially common than dipalmitate; ensure supplier CoA includes purity and residual solvent data [^1_13] The EU classifies Pyridoxine Tripalmitate as "permitted". Safety rating: GOOD.

Is Pyridoxine Tripalmitate allowed in the EU?

Pyridoxine Tripalmitate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pyridoxine Tripalmitate do in cosmetics?

Pyridoxine Tripalmitate functions as: Skin conditioning, emollient (tri-ester of pyridoxine with palmitic acid — more lipophilic than dipalmitate) [^1_13]. It is classified as a cosmetic ingredient in our database. CAS number: 4372-46-7 (referenced) [^1_13].

What is the Margin of Safety for Pyridoxine Tripalmitate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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