Regulatory Status
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Safety Data
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Expert Verdict
DMAPA (3-dimethylaminopropylamine) — a known contact allergen, present as impurity up to 2.45% unless controlled [^1_16]. Ethylene chlorohydrin (ECH) — genotoxic concern, must be ≤ 0.0087% [^1_16]. Nitrosamine formation potential — quaternium-22 can act as a nitrosating agent, releasing potentially carcinogenic nitrosamines [^1_14]. EWG score: 5 (moderate concern) [^1_14].
Regulatory Flags
Frequently Asked Questions
Is Quaternium-22 safe in cosmetics?
DMAPA (3-dimethylaminopropylamine) — a known contact allergen, present as impurity up to 2.45% unless controlled [^1_16]. Ethylene chlorohydrin (ECH) — genotoxic concern, must be ≤ 0.0087% [^1_16]. Nitrosamine formation potential — quaternium-22 can act as a nitrosating agent, releasing potentially carcinogenic nitrosamines [^1_14]. EWG score: 5 (moderate concern) [^1_14]. The EU classifies Quaternium-22 as "permitted". Safety rating: MODERATE.
Is Quaternium-22 allowed in the EU?
Quaternium-22 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Quaternium-22 do in cosmetics?
Quaternium-22 functions as: Antistatic, Film Forming, Hair Conditioning [^1_15]. It is classified as a cosmetic ingredient in our database. CAS number: 51812-80-7 [^1_14].
What is the Margin of Safety for Quaternium-22?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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