Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Quaternium-27. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=300 other | oral | rat | oral | REACH |
| NOAEL | 4000 ppm | oral | dog | oral | REACH |
| NOAEL | >2200 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Tallow-derived — BSE/TSE compliance documentation required for EU market; potential nitrosamine formation if combined with nitrosating agents
Frequently Asked Questions
Is Quaternium-27 safe in cosmetics?
Tallow-derived — BSE/TSE compliance documentation required for EU market; potential nitrosamine formation if combined with nitrosating agents The EU classifies Quaternium-27 as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Quaternium-27 allowed in the EU?
Quaternium-27 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Quaternium-27 do in cosmetics?
Quaternium-27 functions as: Antistatic, hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 68122-86-1.
What is the Margin of Safety for Quaternium-27?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Quaternium-27?
The NOAEL (No Observed Adverse Effect Level) for Quaternium-27 is >=300 other based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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