Rhodiola Rosea Root Extract

INCI: RHODIOLA ROSEA ROOT EXTRACT

CAS Number
None
Function
Skin adaptogen, anti-aging active, antioxidant. Key bioactives: salidroside, rosavins. Mechanisms: stress-skin axis regulation, antioxidant defense, anti-senescence.
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA restrictions. Formal topical adaptogen classification per 2025 PRISMA systematic review. HPLC salidroside and rosavin quantification required per WHO 2025 guidelines.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Rhodiola rosea is classified as a topical adaptogen per the 2025 PRISMA systematic review with safe, homeostatic, and multitargeted properties. Key bioactives are salidroside and rosavins. Documented mechanisms include stress-skin axis regulation, antioxidant activity, and anti-senescence effects. HPLC quantification of salidroside and total rosavins is required per WHO 2025 standardization guidelines for batch consistency.

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Concern Level: Low

Regulatory Flags

adaptogen salidroside-content rosavin-content stress-skin-axis anti-senescence antioxidant hplc-quantification-required who-2025-compliance in-vitro-evidence

Frequently Asked Questions

Is Rhodiola Rosea Root Extract safe in cosmetics?

Rhodiola rosea is classified as a topical adaptogen per the 2025 PRISMA systematic review with safe, homeostatic, and multitargeted properties. Key bioactives are salidroside and rosavins. Documented mechanisms include stress-skin axis regulation, antioxidant activity, and anti-senescence effects. HPLC quantification of salidroside and total rosavins is required per WHO 2025 standardization guidelines for batch consistency. The EU classifies Rhodiola Rosea Root Extract as "permitted". Safety rating: GOOD.

Is Rhodiola Rosea Root Extract allowed in the EU?

Rhodiola Rosea Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Rhodiola Rosea Root Extract do in cosmetics?

Rhodiola Rosea Root Extract functions as: Skin adaptogen, anti-aging active, antioxidant. Key bioactives: salidroside, rosavins. Mechanisms: stress-skin axis regulation, antioxidant defense, anti-senescence.. It is classified as a cosmetic ingredient in our database. CAS number: None.

What is the Margin of Safety for Rhodiola Rosea Root Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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