Riboflavin Tetrabutyrate

INCI: RIBOFLAVIN TETRABUTYRATE [^1_2]

CAS Number
752-56-7 [^1_1]
Function
Antioxidant, skin conditioning agent, colorant (lipophilic vitamin B2 derivative) [^1_3][^1_4]
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted for cosmetic use; no specific restrictions. Riboflavin derivatives are GRAS in food, no FDA monograph restriction for topical cosmetics [^1_3]

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Photosensitizer potential: riboflavin is a known photosensitizer that generates reactive oxygen species under UV โ€” use with caution in leave-on products with sun exposure; may cause yellow staining of formulations [^1_5]

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Concern Level: Moderate

Regulatory Flags

potential-allergen colorant

Frequently Asked Questions

Is Riboflavin Tetrabutyrate safe in cosmetics?

Photosensitizer potential: riboflavin is a known photosensitizer that generates reactive oxygen species under UV โ€” use with caution in leave-on products with sun exposure; may cause yellow staining of formulations [^1_5] The EU classifies Riboflavin Tetrabutyrate as "restricted". Safety rating: GOOD.

Is Riboflavin Tetrabutyrate allowed in the EU?

Riboflavin Tetrabutyrate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Riboflavin Tetrabutyrate do in cosmetics?

Riboflavin Tetrabutyrate functions as: Antioxidant, skin conditioning agent, colorant (lipophilic vitamin B2 derivative) [^1_3][^1_4]. It is classified as a cosmetic ingredient in our database. CAS number: 752-56-7 [^1_1].

What is the Margin of Safety for Riboflavin Tetrabutyrate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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