Riboflavin Tetraacetate

INCI: RIBOFLAVIN TETRAACETATE [^1_17]

CAS Number
752-13-6 [^1_16]
Function
Skin conditioning [^1_17]
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; vitamin B2 derivative recognized for cosmetic use [^1_18]

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Photosensitivity: riboflavin is a known photosensitizer โ€” generates reactive oxygen species under UV. Recommend SPF co-formulation or restrict to night/rinse-off products. Molecular weight 544.51 Da [^1_16][^1_17]

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Riboflavin Tetraacetate safe in cosmetics?

Photosensitivity: riboflavin is a known photosensitizer โ€” generates reactive oxygen species under UV. Recommend SPF co-formulation or restrict to night/rinse-off products. Molecular weight 544.51 Da [^1_16][^1_17] The EU classifies Riboflavin Tetraacetate as "permitted". Safety rating: GOOD.

Is Riboflavin Tetraacetate allowed in the EU?

Riboflavin Tetraacetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Riboflavin Tetraacetate do in cosmetics?

Riboflavin Tetraacetate functions as: Skin conditioning [^1_17]. It is classified as a cosmetic ingredient in our database. CAS number: 752-13-6 [^1_16].

What is the Margin of Safety for Riboflavin Tetraacetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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