Ribonic Acid

INCI: RIBONIC ACID [^1_6]

CAS Number
642-98-8 [^1_6]
Function
Skin conditioning, humectant (sugar acid/polyhydroxy acid — oxidation product of ribose) [^1_6]
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted for cosmetic use; no specific restrictions or monograph requirements [^1_6]

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

At higher concentrations may lower formulation pH significantly — monitor pH to avoid irritation; limited published SCCS safety dossier data compared to gluconolactone [^1_6]

⚠️
Concern Level: Moderate

Frequently Asked Questions

Is Ribonic Acid safe in cosmetics?

At higher concentrations may lower formulation pH significantly — monitor pH to avoid irritation; limited published SCCS safety dossier data compared to gluconolactone [^1_6] The EU classifies Ribonic Acid as "permitted". Safety rating: GOOD.

Is Ribonic Acid allowed in the EU?

Ribonic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ribonic Acid do in cosmetics?

Ribonic Acid functions as: Skin conditioning, humectant (sugar acid/polyhydroxy acid — oxidation product of ribose) [^1_6]. It is classified as a cosmetic ingredient in our database. CAS number: 642-98-8 [^1_6].

What is the Margin of Safety for Ribonic Acid?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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