Is Ruscogenin safe in cosmetics?
Ruscogenin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Ruscogenin
Also known as: (1beta,3beta,25R)-Spirost-5-ene-1,3-diol, (25R)-Spirost-5-ene-1beta,3beta-diol, EINECS 207-447-2
INCI: RUSCOGENIN
Ruscogenin (CAS 472-11-7) is a cosmetic cosmetic ingredient functioning as Skin Protecting Agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 472-11-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Protecting Agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,14R,16R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol
InChIKey
QMQIQBOGXYYATH-IDABPMKMSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use; CIR has assessed Ruscus-derived ingredients
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ruscogenin.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "caution", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "circulation", "skin_benefit_secondary": "vein-toning", "mec…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Ruscogenin.
Known Synonyms
(1beta,3beta,25R)-Spirost-5-ene-1,3-diol
(25R)-Spirost-5-ene-1beta,3beta-diol
EINECS 207-447-2
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
RUSCOGENIN
ChEMBL ID
CHEMBL1169820
Frequently Asked Questions
Is Ruscogenin allowed in the EU?
Ruscogenin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ruscogenin do in cosmetics?
Ruscogenin functions as: Skin Protecting Agent. It is classified as a cosmetic ingredient in our database. CAS number: 472-11-7.
Is Ruscogenin used outside cosmetics?
Ruscogenin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ruscogenin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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