Good Cosmetic Ingredient

Salicin

INCI: SALICIN

CAS Number
138-52-3
Function
Skin conditioning; anti-inflammatory (metabolized to salicylic acid); soothing agent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted cosmetic ingredient; FDA UNII: 4649620TBZ; not an OTC drug active per FDA when used as cosmetic

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Key concern: metabolic conversion to salicylic acid — must account for total salicylate load in formula; SCCS warns salicylic acid is an eye irritant with potential for serious eye damage; not suitable for sprayable products that may lead to lung inhalation exposure; avoid in products for children under 3 years (EU requirement for salicylic acid); consider regulatory overlap with salicylic acid restrictions

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Concern Level: Low

Frequently Asked Questions

Is Salicin safe in cosmetics?

Key concern: metabolic conversion to salicylic acid — must account for total salicylate load in formula; SCCS warns salicylic acid is an eye irritant with potential for serious eye damage; not suitable for sprayable products that may lead to lung inhalation exposure; avoid in products for children under 3 years (EU requirement for salicylic acid); consider regulatory overlap with salicylic acid restrictions The EU classifies Salicin as "permitted". Safety rating: GOOD.

Is Salicin allowed in the EU?

Salicin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Salicin do in cosmetics?

Salicin functions as: Skin conditioning; anti-inflammatory (metabolized to salicylic acid); soothing agent. It is classified as a cosmetic ingredient in our database. CAS number: 138-52-3.

What is the Margin of Safety for Salicin?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Salicin compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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