Is Salicin safe in cosmetics?
Salicin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Salicin
Also known as: B-D-Glucopyranoside, 2-(hydroxymethyl)phenyl, beta-D-Glucopyranoside, 2-(hydroxymethyl)phenyl, o-(Hydroxymethyl)phenyl β-D-glucopyranoside, .beta.-D-Glucopyranoside, 2-(hydroxymethyl)phenyl, β-D-Glucopyranoside, 2-(hydroxymethyl)phenyl (+8 more)
INCI: SALICIN
Salicin (CAS 138-52-3) is a cosmetic cosmetic ingredient functioning as Skin conditioning; anti-inflammatory (metabolized to salicylic acid); soothing. Reported NOAEL =1000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 138-52-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; anti-inflammatory (metabolized to salicylic acid); soothing agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[2-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
InChIKey
NGFMICBWJRZIBI-UJPOAAIJSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted cosmetic ingredient; FDA UNII: 4649620TBZ; not an OTC drug active per FDA when used as cosmetic
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Salicin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Salicin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Salicin.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Salicin by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
B-D-Glucopyranoside, 2-(hydroxymethyl)phenyl
beta-D-Glucopyranoside, 2-(hydroxymethyl)phenyl
o-(Hydroxymethyl)phenyl β-D-glucopyranoside
.beta.-D-Glucopyranoside, 2-(hydroxymethyl)phenyl
β-D-Glucopyranoside, 2-(hydroxymethyl)phenyl
2-(Hydroxymethyl)phenyl β-D-glucopyranoside
Salicyl alcohol glucoside
Saligenin β-D-glucopyranoside
1-β-D-Glucosyloxy-2-hydroxymethylbenzene
alpha-Hydroxy-o-tolyl beta-D-glucopyranoside
Salicine
Salicoside
D-Salicin
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SALICIN
ChEMBL ID
CHEMBL462997
Max Phase
-1
Frequently Asked Questions
Is Salicin allowed in the EU?
Salicin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Salicin do in cosmetics?
Salicin functions as: Skin conditioning; anti-inflammatory (metabolized to salicylic acid); soothing agent. It is classified as a cosmetic ingredient in our database. CAS number: 138-52-3.
What is the NOAEL for Salicin?
The NOAEL (No Observed Adverse Effect Level) for Salicin is =1000 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Salicin used outside cosmetics?
Salicin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Salicin compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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