NOAEL Studies Antioxidant

Sodium Ascorbate NOAEL Studies

INCI: SODIUM ASCORBATE

CAS: 134-03-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 364 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 750 mg/kg bw/day mouse oral NA Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1250 mg/kg bw/day rat oral 126 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 1365 mg/kg bw/day rat oral 168 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day rat oral 231 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3420 mg/kg bw/day rat oral 70 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5000 mg/kg bw/day rat oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 7500 mg/kg bw/day mouse oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=14588; RecordID=ARPathway2016_795; DatasetName=ARPathway2016; DTXSID=DTXSID0020105; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020105
ToxValDB_ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =5 % Rat oral subchronic; 56 days subchronic LONG_REF=Toxicol. Appl. Pharmacol.99(1): 37-49 Shibata,M.A., M. Yamada, H. Tanaka, M. Kagawa, and S. Fukushima Changes in Urine Composition, Bladder Epithelial Morphology, and DNA Synthesis in Male F344 Rats in Response to Ingestion of Bladder Tumor Promoters 1989; TITLE=Changes in Urine Composition, Bladder Epithelial Morphology, and DNA Synthesis in Male F344 Rats in Response to Ingestion of Bladder Tumor Promoters; AUTHOR=Shibata,M.A., M. Yamada, H. Tanaka, M. Kagawa, and S. Fukushima; DOI=10.1016/0041-008x(89)90109-9; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=106692; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: pH|Genetics: DNA synthesis rate|Physiology: Osmolality; TOXICOLOGICAL_EFFECT_CATEGORY=other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603430_15603431:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1abea14880040618580850faa47499a8
ToxValDB_ECOTOX LOEL =6.84 % diet Rat oral subchronic; 70 days subchronic LONG_REF=Carcinogenesis16(2): 343-348 Cohen,S.M., M. Cano, E.M. Garland, M. St.John, and L.L. Arnold Urinary and Urothelial Effects of Sodium Salts in Male Rats 1995; TITLE=Urinary and Urothelial Effects of Sodium Salts in Male Rats; AUTHOR=Cohen,S.M., M. Cano, E.M. Garland, M. St.John, and L.L. Arnold; DOI=10.1093/carcin/16.2.343; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=111191; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Biochemistry: pH|Growth: Weight|Histology: Hyperplasia|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15609045_15609046:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=eeccab7a91a57cffedadb81a85674ce8
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier S033EH8359 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7O6.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S033EH8359"}
openFDA substances FDA UNII substance identifier S033EH8359 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7O6.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S033EH8359"}
openFDA substances FDA UNII substance identifier S033EH8359 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7O6.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S033EH8359"}
openFDA substances FDA UNII substance identifier S033EH8359 UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7O6.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"S033EH8359"}