Good Cosmetic Ingredient NOAEL Data

Sodium Hydrolyzed Casein

INCI: SODIUM HYDROLYZED CASEIN

CAS Number
68131-72-6
Function
Hair Conditioning, Skin Conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; CIR reviewed hydrolyzed milk proteins โ€” safe with peptide length restriction (minimize chains >30 amino acids)

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Sodium Hydrolyzed Casein. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 1000 mg/kg bw/day oral rat oral REACH

Expert Verdict

Milk allergen source โ€” disclosure required; CIR recommends avoiding use on damaged skin/mucous membranes and in products that may be inhaled

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Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Sodium Hydrolyzed Casein safe in cosmetics?

Milk allergen source โ€” disclosure required; CIR recommends avoiding use on damaged skin/mucous membranes and in products that may be inhaled The EU classifies Sodium Hydrolyzed Casein as "permitted". Safety rating: GOOD. 1 toxicological study endpoint(s) are available in our database.

Is Sodium Hydrolyzed Casein allowed in the EU?

Sodium Hydrolyzed Casein EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Hydrolyzed Casein do in cosmetics?

Sodium Hydrolyzed Casein functions as: Hair Conditioning, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 68131-72-6.

What is the Margin of Safety for Sodium Hydrolyzed Casein?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Sodium Hydrolyzed Casein?

The NOAEL (No Observed Adverse Effect Level) for Sodium Hydrolyzed Casein is 1000 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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