Sodium Hydroxymethylglycinate
INCI: SODIUM HYDROXYMETHYLGLYCINATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Sodium Hydroxymethylglycinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=160 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 640 mg/kg bw/day | oral | rat | oral | REACH |
Sensitization Profile
Contact sensitization data for Sodium Hydroxymethylglycinate based on clinical patch test studies and IFRA standards.
Source: ESSCA 2019/20; IVDK; FDA
Dermal Penetration Profile
Skin absorption and penetration characteristics of Sodium Hydroxymethylglycinate, relevant to systemic exposure and MoS calculations.
Source: SCCS Opinion
Expert Verdict
Formaldehyde releaser often positioned as a natural preservative due to amino acid structure. EU Annex V restricted at 0.5%. Washington State ban effective January 1, 2027. Released formaldehyde is an IARC Group 1 carcinogen. Moderate sensitization risk. Marketing as gentle or natural does not eliminate formaldehyde release mechanism.
Regulatory Flags
Frequently Asked Questions
Is Sodium Hydroxymethylglycinate safe in cosmetics?
Formaldehyde releaser often positioned as a natural preservative due to amino acid structure. EU Annex V restricted at 0.5%. Washington State ban effective January 1, 2027. Released formaldehyde is an IARC Group 1 carcinogen. Moderate sensitization risk. Marketing as gentle or natural does not eliminate formaldehyde release mechanism. The EU classifies Sodium Hydroxymethylglycinate as "restricted". Safety rating: MODERATE. 2 toxicological study endpoint(s) are available in our database.
Is Sodium Hydroxymethylglycinate allowed in the EU?
Sodium Hydroxymethylglycinate EU regulatory status: restricted. Maximum allowed concentration: 0.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Hydroxymethylglycinate do in cosmetics?
Sodium Hydroxymethylglycinate functions as: Preservative. It is classified as a Preservative in our database. CAS number: 70161-44-3.
What is the Margin of Safety for Sodium Hydroxymethylglycinate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Hydroxymethylglycinate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Hydroxymethylglycinate is >=160 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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