Is Sodium Propylparaben safe in cosmetics?
Sodium Propylparaben has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.
Sodium Propylparaben
Also known as: Caswell No. 714A, EINECS 252-488-1, EPA Pesticide Chemical Code 061204, Propyl p-hydroxybenzoate, sodium salt, Natrium propyl 4-hydroxybenzoat (+5 more)
INCI: SODIUM PROPYLPARABEN
Sodium Propylparaben (CAS 35285-69-9) is a cosmetic cosmetic ingredient functioning as Preservative (antimicrobial); water-soluble sodium salt form of propylparaben. NOAEL 980.9 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted, max 0.14%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 35285-69-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Sodium Propylparaben is classified GHS Danger (H318, H412) in the chemicals database but is allowed in EU cosmetics at max 0.14%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Preservative (antimicrobial); water-soluble sodium salt form of propylparaben
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
sodium 4-propoxycarbonylphenolate
InChIKey
IXMINYBUNCWGER-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.14%
US US Status
permitted
US Notes
Permitted; listed as an approved preservative in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Propylparaben.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Sodium Propylparaben. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =980.9 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1076.4 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1124.6 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Sodium Propylparaben across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for Sodium Propylparaben based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
0.2%
Cross-reactivity Group
paraben-group
Reaction Type
contact-dermatitis
Source: ESSCA; IVDK; SCCS/1348/10
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "preservative", "cross_reactivity_group": "paraben-group", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "ESSCA; IVDK; SCCS/1348/10"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Preservative
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Propylparaben.
Regulatory Flags
preservative
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Propylparaben by CAS number or substance name.
Studies
3
Lowest NOAEL
980.9 mg/kg bw/day
Highest NOAEL
1124.6 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Caswell No. 714A
EINECS 252-488-1
EPA Pesticide Chemical Code 061204
Propyl p-hydroxybenzoate, sodium salt
Natrium propyl 4-hydroxybenzoat
Propyl-4-hydroxybenzoat natriumsalz
UNII-625NNB0G9N
Propyl 4-hydroxybenzoate sodium salt
Sodium propyl hydroxybenzoate
Benzoic acid, 4-hydroxy-, propyl ester, sodium salt
Chemical Function
Preservative
Biocide
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PROPYLPARABEN SODIUM
ChEMBL ID
CHEMBL2107021
Max Phase
-1
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Sodium propyl 4-hydroxybenzoate
E Number
E217
ADI
10 mg/kg bw
Food Category
preservative
Frequently Asked Questions
Is Sodium Propylparaben allowed in the EU?
Sodium Propylparaben EU regulatory status: permitted. Maximum allowed concentration: 0.14%. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Propylparaben do in cosmetics?
Sodium Propylparaben functions as: Preservative (antimicrobial); water-soluble sodium salt form of propylparaben. It is classified as a cosmetic ingredient in our database. CAS number: 35285-69-9.
What is the NOAEL for Sodium Propylparaben?
The NOAEL (No Observed Adverse Effect Level) for Sodium Propylparaben is =980.9 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Sodium Propylparaben used outside cosmetics?
Sodium Propylparaben also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Sodium Propylparaben have different safety status in cosmetics vs industrial chemicals?
Sodium Propylparaben is classified GHS Danger (H318, H412) in the chemicals database but is allowed in EU cosmetics at max 0.14%.
Compliance Tools
Check Sodium Propylparaben compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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