Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Sorbitan Isostearate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 2300 other | oral | rat | oral | REACH |
| NOAEL | >638 mg/kg bw/day | oral | dog | oral | REACH |
| NOAEL | >=5 other | oral | rat | oral | REACH |
| NOAEL | >=5000 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 5 other | oral | rat | oral | REACH |
| NOAEL | 5 other | oral | rat | oral | REACH |
| NOAEL | 5 other | oral | rat | oral | REACH |
| NOAEL | 2300 other | oral | rat | oral | REACH |
| LOAEL | 15 other | oral | rat | oral | REACH |
Expert Verdict
Sorbitan Isostearate is generally considered safe for use as a cosmetic ingredient.
Frequently Asked Questions
Is Sorbitan Isostearate safe in cosmetics?
Sorbitan Isostearate is generally considered safe for use as a cosmetic ingredient. The EU classifies Sorbitan Isostearate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Sorbitan Isostearate allowed in the EU?
Sorbitan Isostearate EU regulatory status: permitted. Maximum allowed concentration: 2.3%. This is based on EU Regulation 1223/2009 and its amendments.
What does Sorbitan Isostearate do in cosmetics?
Sorbitan Isostearate functions as: Emulsifier. It is classified as a Cosmetic Ingredient in our database. CAS number: 71902-01-7.
What is the Margin of Safety for Sorbitan Isostearate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sorbitan Isostearate?
The NOAEL (No Observed Adverse Effect Level) for Sorbitan Isostearate is >=1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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