Sphinganine

INCI: SPHINGANINE

CAS Number
3102-56-5 (D-erythro-sphinganine / dihydrosphingosine)
Function
Skin conditioning, hair conditioning; ceramide precursor that supports barrier function
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; CIR Panel concluded "safe as used" within the ceramides family assessment

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

If animal-derived, must not originate from bovine CNS tissue (BSE/TSE risk per 21 CFR 700.27 and EU regulations); plant-derived or synthetic forms preferred

โš ๏ธ
Concern Level: Low

Regulatory Flags

natural-origin

Frequently Asked Questions

Is Sphinganine safe in cosmetics?

If animal-derived, must not originate from bovine CNS tissue (BSE/TSE risk per 21 CFR 700.27 and EU regulations); plant-derived or synthetic forms preferred The EU classifies Sphinganine as "permitted". Safety rating: GOOD.

Is Sphinganine allowed in the EU?

Sphinganine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sphinganine do in cosmetics?

Sphinganine functions as: Skin conditioning, hair conditioning; ceramide precursor that supports barrier function. It is classified as a cosmetic ingredient in our database. CAS number: 3102-56-5 (D-erythro-sphinganine / dihydrosphingosine).

What is the Margin of Safety for Sphinganine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

๐Ÿ“ฑ

Is Sphinganine in Your Products?

Scan any product label with Piro โ€” our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free โ†’

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Sphinganine in your formulation.