NOAEL Studies UV Filter / Sunscreen

Sulisobenzone (Benzophenone-4) NOAEL Studies

INCI: SULISOBENZONE

CAS: 4065-45-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP ICE acute oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =3530 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_6313; row=4765; data_type=In Vivo; mixture=Chemical; chemical_name=Sulisobenzone; preferred_name=Sulisobenzone; dtxsid=DTXSID2042436; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2042436; source_file=acute_oral.xlsx
NTP ICE adme parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE adme parameters Clint 1.05 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=1042; Record_ID=adme_parameters_1081; Data_Type=Measured; DTXSID=DTXSID2042436; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=1.05; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2042436
NTP ICE adme parameters Fu 0.00942 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=1043; Record_ID=adme_parameters_1081; Data_Type=Measured; DTXSID=DTXSID2042436; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.00942; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2042436
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=14988; RecordID=ARPathway2016_1192; DatasetName=ARPathway2016; DTXSID=DTXSID2042436; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2042436
SCCS Opinion 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
SCCS Opinion NOAEL =59 - - - - NOAEL study p.59
SCCS Opinion NOAEL =620 mg/kg bw/day rat oral 90-day repeated dose toxicity p.59
SCCS Opinion NOAEL =620 - - - - NOAEL study p.59
SCCS Opinion NOAEL =1239 mg/kg/day rat - 90-day NOAEL study p.37
SCCS Opinion NOAEL =1239 mg/kg bw/day rat oral 90-day repeated dose toxicity p.59
SCCS Opinion NOAEL =1250 mg/kg/day rat - - NOAEL study p.38
ToxValDB GESTIS DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =10 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635016_15635017:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_787f71bce80e8c9aab57060e8e3efeda
ToxValDB GESTIS DNEL DNEL systemic =61.7 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15635016_15635017:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5ec3b5a11e24024d422ff47a649bbf50
Regulatory source 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
Regulatory source - 59 - - - - - p.59
Regulatory source - 620 - - - - - p.59
Regulatory source - 620 - - dermal - - p.59
Regulatory source - 1239 mg/kg/day rat - 90-day - p.37
Regulatory source - 1250 mg/kg/day rat - - - p.38
Regulatory source repeated dose toxicity 620 mg/kg bw/day rat oral 90-day repeated dose toxicity p.59
Regulatory source repeated dose toxicity 1239 mg/kg bw/day rat oral 90-day repeated dose toxicity p.59
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 1W6L629B4K UNII - - - chemical -