Moderate Cosmetic Ingredient NOAEL Data GHS Classified

t-Butyl Methyl Ether

INCI: TERT-BUTYL METHYL ETHER

CAS Number

1634-04-4

Function

Solvent

Safety Rating

MODERATE

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes Not specifically regulated for cosmetics; permitted under general use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

adequate

Dermal Absorption

moderate

Sensitization

low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for t-Butyl Methyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	3000 mg/L drinking water	oral	rat	oral	REACH
LOAEL	357 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	90 mg/kg bw/day	oral	rat	oral	REACH
LOAEL	200 mg/kg bw/day	oral	rat	oral	REACH
LOAEL	250 mg/kg bw/day	oral	rat	oral	REACH
NOAEL	10000 2106	1995	rat	inhalation	REACH
NOAEL	480 mg/L drinking water	oral	rat	oral	REACH
LOAEL	400 mg/kg bw/day	oral	rat	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects

The substance is irritating to the skin. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure far above the OEL could cause lowering of consciousness.

Routes of Exposure

The substance can be absorbed into the body by inhalation and by ingestion.

Expert Verdict

Suspected endocrine disruptor; skin irritant; persistent environmental pollutant; air contamination risk

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Concern Level: Moderate

Frequently Asked Questions

Is t-Butyl Methyl Ether safe in cosmetics?

Suspected endocrine disruptor; skin irritant; persistent environmental pollutant; air contamination risk The EU classifies t-Butyl Methyl Ether as "permitted". Safety rating: MODERATE. 8 toxicological study endpoint(s) are available in our database.

Is t-Butyl Methyl Ether allowed in the EU?

t-Butyl Methyl Ether EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does t-Butyl Methyl Ether do in cosmetics?

t-Butyl Methyl Ether functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 1634-04-4.

What is the Margin of Safety for t-Butyl Methyl Ether?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for t-Butyl Methyl Ether?

The NOAEL (No Observed Adverse Effect Level) for t-Butyl Methyl Ether is 3000 mg/L drinking water based on a oral study via oral route in rat. A total of 8 study endpoints are available. Source: REACH.

Compliance Tools

Check t-Butyl Methyl Ether compliance across multiple jurisdictions:

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Ingredient Decoder

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

Calculate Margin of Safety using SCCS methodology

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Heavy Metal Limits

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