NOAEL Studies
Antioxidant
Taurine NOAEL Studies
INCI: TAURINE
CAS: 107-35-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 50 | mg/kg bw/day | mouse | oral | 365 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 462 | mg/kg bw/day | guinea pig | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 565 | mg/kg bw/day | guinea pig | oral | 5 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 700 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2000 | mg/kg bw/day | rat | oral | 30 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2500 | mg/kg bw/day | mouse | oral | NA | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 5000 | mg/kg bw/day | rat | oral | 56 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=a78ac3ed-b7a3-4868-b365-82f4d40fe87e_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=a78ac3ed-b7a3-4868-b365-82f4d40fe87e/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-12-26; basis=behaviour (functional findings); key_result=true; entry_uuid=1b0779f0-6024-4e2d-8906-c659eca2875d |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 50 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral, other | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=2cb86204-0415-4297-a38a-aaa12b2e2056_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=2cb86204-0415-4297-a38a-aaa12b2e2056/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=RepeatedDoseToxicityOral; basis=haematology; key_result=false; entry_uuid=f1ab7632-ec85-4976-ae26-954eab9ff4c3 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=a78ac3ed-b7a3-4868-b365-82f4d40fe87e_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=a78ac3ed-b7a3-4868-b365-82f4d40fe87e/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-12-26; basis=behaviour (functional findings); key_result=true; entry_uuid=1b0779f0-6024-4e2d-8906-c659eca2875d |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 50 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral, other | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=2cb86204-0415-4297-a38a-aaa12b2e2056_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=2cb86204-0415-4297-a38a-aaa12b2e2056/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=RepeatedDoseToxicityOral; basis=haematology; key_result=false; entry_uuid=f1ab7632-ec85-4976-ae26-954eab9ff4c3 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | sub-chronic toxicity: oral | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=a78ac3ed-b7a3-4868-b365-82f4d40fe87e_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=a78ac3ed-b7a3-4868-b365-82f4d40fe87e/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2001; ReportDate=2001-12-26; basis=behaviour (functional findings); key_result=true; entry_uuid=1b0779f0-6024-4e2d-8906-c659eca2875d |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 50 | mg/kg bw/day | rat | oral: gavage | - | repeated dose toxicity: oral, other | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=2cb86204-0415-4297-a38a-aaa12b2e2056_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=2cb86204-0415-4297-a38a-aaa12b2e2056/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=RepeatedDoseToxicityOral; basis=haematology; key_result=false; entry_uuid=f1ab7632-ec85-4976-ae26-954eab9ff4c3 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 7000 | mg/kg bw/day | mouse | oral: unspecified | - | three-generation reproductive toxicity | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=484b0a15-bdf1-4b02-aec6-f062392aa277_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=484b0a15-bdf1-4b02-aec6-f062392aa277/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-05-13; key_result=false; entry_uuid=fcbf4226-06f8-4159-b0e3-549d968db2c7 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 3000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=ecca2a52-093d-4c21-9593-c58a10552351_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=ecca2a52-093d-4c21-9593-c58a10552351/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1981; key_result=false; entry_uuid=62f5faa9-bfa1-4dc8-ae2e-e6ada2fa90c1 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 7000 | mg/kg bw/day | mouse | oral: unspecified | - | three-generation reproductive toxicity | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=484b0a15-bdf1-4b02-aec6-f062392aa277_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=484b0a15-bdf1-4b02-aec6-f062392aa277/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-05-13; key_result=false; entry_uuid=fcbf4226-06f8-4159-b0e3-549d968db2c7 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 3000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=ecca2a52-093d-4c21-9593-c58a10552351_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=ecca2a52-093d-4c21-9593-c58a10552351/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1981; key_result=false; entry_uuid=62f5faa9-bfa1-4dc8-ae2e-e6ada2fa90c1 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 7000 | mg/kg bw/day | mouse | oral: unspecified | - | three-generation reproductive toxicity | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=484b0a15-bdf1-4b02-aec6-f062392aa277_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=484b0a15-bdf1-4b02-aec6-f062392aa277/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-05-13; key_result=false; entry_uuid=fcbf4226-06f8-4159-b0e3-549d968db2c7 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 3000 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6z; document=ecca2a52-093d-4c21-9593-c58a10552351_ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50.i6d; document_key=ecca2a52-093d-4c21-9593-c58a10552351/ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1981; key_result=false; entry_uuid=62f5faa9-bfa1-4dc8-ae2e-e6ada2fa90c1 |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =1000 | mg/kg bw/day | Rat | oral: gavage | 91 days | subchronic | EFSA ANS - 2009 - OutputID 574 - no adverse effect observed at single/highest dose - The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called “energy” drinks - doi:10.2903/j.efsa.2009.935 |
ToxValDB_ECHA_IUCLID 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =100 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0daf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/26194/7/6/2?documentUUID=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840784_15850304:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_88de7e55e32ed7eb1e5b535e87ad9d2b |
| ToxValDB_ECHA_IUCLID | LOAEL | =50 | mg/kg bw/day | Rat | oral | subchronic; 60 days | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0da9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/26194/7/6/2?documentUUID=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=ECHA IUCLID:15850303:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3bfef70da5222f02c130abf09f31207b |
| ToxValDB_ECHA_IUCLID | LOAEL | =300 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaccce4b0a7c65d1c0daf; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/26194/7/6/2?documentUUID=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=behaviour (functional findings)|clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|neurobehavior; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15840784_15850304:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2e5b2ee7ab1220e776a41ba4b01562dc |
| ToxValDB_ECHA_IUCLID | NOAEL | =3000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb6d6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/26194/7/9/3?documentUUID=ac1d0540-9e4c-4c95-a5c4-34c54ad4fc50; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID:15823952:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_507727e2cc88540112d2db543237d4a7 |
ToxValDB_ECOTOX 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | NOEL | =50 | mg/kg bw/day | Rat | injection | subchronic; 48 days | subchronic | LONG_REF=Food Chem. Toxicol.47(7): 1676-1684 Ozden,S., B. Catalgol, S. Gezginci-Oktayoglu, P. Arda-Pirincci, S. Bolkent, and B. Alpertunga Methiocarb-Induced Oxidative Damage Following Subacute Exposure and the Protective Effects of Vitamin E and Taurine in Rats 2009; TITLE=Methiocarb-Induced Oxidative Damage Following Subacute Exposure and the Protective Effects of Vitamin E and Taurine in Rats; AUTHOR=Ozden,S., B. Catalgol, S. Gezginci-Oktayoglu, P. Arda-Pirincci, S. Bolkent, and B. Alpertunga; DOI=10.1016/j.fct.2009.04.018; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=116326; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Biochemistry: Malondialdehyde|Enzyme(s): Catalase|Enzyme(s): Glutathione peroxidase|Enzyme(s): Glutathione reductase|Enzyme(s): Superoxide dismutase (SOD) enzyme activity; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX:15595665:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ecb2231a4c7a4532939040488b46aebb |
| ToxValDB_ECOTOX | NOEL | =300 | mg/kg bw/day | Rat | injection | chronic; 182 days | chronic | LONG_REF=J. Gastroenterol.32(4): 435-441 Iishi,H., M. Tatsuta, M. Baba, T. Mikuni, R. Yamamoto, K. Iseki, H. Yano, H. Uehara, and A. Nakaizumi Enhancement by Monochloramine of the Development of Gastric Cancers in Rats: a Possible Mechanism of Helicobacter pylori-Associated Gastric Carcinogenesis 1997; TITLE=Enhancement by Monochloramine of the Development of Gastric Cancers in Rats: a Possible Mechanism of Helicobacter pylori-Associated Gastric Carcinogenesis; AUTHOR=Iishi,H., M. Tatsuta, M. Baba, T. Mikuni, R. Yamamoto, K. Iseki, H. Yano, H. Uehara, and A. Nakaizumi; DOI=10.1007/BF02934080; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151911; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Cell(s): Cell changes|Growth: Weight|Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15603630:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4bde9d773311f54545a99390eb8857b6 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =1000 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=EFSA ANS (2009). The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called "energy" drinks. doi:10.2903/j.efsa.2009.935.; TITLE=The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called "energy" drinks; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2009.935; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15614145:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bcf9222a66a10c2f6e21c2986e11922b |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 1EQV5MLY3D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H7NO3S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1EQV5MLY3D"} |
| openFDA substances | FDA UNII substance identifier | 1EQV5MLY3D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H7NO3S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1EQV5MLY3D"} |
| openFDA substances | FDA UNII substance identifier | 1EQV5MLY3D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H7NO3S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1EQV5MLY3D"} |
| openFDA substances | FDA UNII substance identifier | 1EQV5MLY3D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C2H7NO3S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1EQV5MLY3D"} |