Good Cosmetic Ingredient NOAEL Data

Tetrahydro-dimethylbenzofuran

INCI: TETRAHYDRO-DIMETHYLBENZOFURAN

CAS Number
494-90-6
Function
Fragrance – herbal, minty-camphoraceous; also used in flavoring
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted under FDA 21 CFR 172; FEMA 3235 (GRAS); TSCA listed

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Tetrahydro-dimethylbenzofuran. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 250 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
NOAEL 200 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB

Expert Verdict

Flammable liquid (H227); NFPA Health hazard: 0 (minimal); not classified for acute toxicity, carcinogenicity, or mutagenicity

⚠️
Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Tetrahydro-dimethylbenzofuran safe in cosmetics?

Flammable liquid (H227); NFPA Health hazard: 0 (minimal); not classified for acute toxicity, carcinogenicity, or mutagenicity The EU classifies Tetrahydro-dimethylbenzofuran as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is Tetrahydro-dimethylbenzofuran allowed in the EU?

Tetrahydro-dimethylbenzofuran EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetrahydro-dimethylbenzofuran do in cosmetics?

Tetrahydro-dimethylbenzofuran functions as: Fragrance – herbal, minty-camphoraceous; also used in flavoring. It is classified as a cosmetic ingredient in our database. CAS number: 494-90-6.

What is the Margin of Safety for Tetrahydro-dimethylbenzofuran?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Tetrahydro-dimethylbenzofuran?

The NOAEL (No Observed Adverse Effect Level) for Tetrahydro-dimethylbenzofuran is 250 mg/kg bw/day based on a Special Toxicology Study study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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