Is Tetrahydroxyethyl Ethylenediamine safe in cosmetics?
Tetrahydroxyethyl Ethylenediamine has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Cosmetic Ingredient
Tetrahydroxyethyl Ethylenediamine
Also known as: Ethanol, 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetrakis-, EINECS 205-396-0, Ethylenediamine tetraethanol, Ethylenediamine, N,N,N',N'-tetrakis(2-hydroxyethyl)-, 2,2',2'',2'''-(Ethylenediimino)tetraethanol (+8 more)
INCI: TETRAHYDROXYETHYL ETHYLENEDIAMINE
Tetrahydroxyethyl Ethylenediamine (CAS 140-07-8) is a cosmetic cosmetic ingredient functioning as Chelating/sequestering agent, buffering agent, viscosity adjustor. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 140-07-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tetrahydroxyethyl Ethylenediamine is classified GHS Danger (H302, H315, H318) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Chelating/sequestering agent, buffering agent, viscosity adjustor
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[2-[bis(2-hydroxyethyl)amino]ethyl-(2-hydroxyethyl)amino]ethanol
InChIKey
BYACHAOCSIPLCM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted; permitted for cosmetic use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydroxyethyl Ethylenediamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Tetrahydroxyethyl Ethylenediamine.
Known Synonyms
Ethanol, 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetrakis-
EINECS 205-396-0
Ethylenediamine tetraethanol
Ethylenediamine, N,N,N',N'-tetrakis(2-hydroxyethyl)-
2,2',2'',2'''-(Ethylenediimino)tetraethanol
Ethylenedinitrilotetraethanol
NSC 21705
Tetra(hydroxyethyl)ethylenediamine
N,N,N',N'-Tetrakis(2-hydroxyethyl)-1,2-diaminoethane
Tetrakis(hydroxyethyl)ethylenediamine
N,N,N',N'-Tetrakis(hydroxyethyl)ethylenediamine
N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine
UNII-K5APE098ZI
Chemical Function
Chelating agent
pH regulating agent
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3187444
Frequently Asked Questions
Is Tetrahydroxyethyl Ethylenediamine allowed in the EU?
Tetrahydroxyethyl Ethylenediamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydroxyethyl Ethylenediamine do in cosmetics?
Tetrahydroxyethyl Ethylenediamine functions as: Chelating/sequestering agent, buffering agent, viscosity adjustor. It is classified as a cosmetic ingredient in our database. CAS number: 140-07-8.
Is Tetrahydroxyethyl Ethylenediamine used outside cosmetics?
Tetrahydroxyethyl Ethylenediamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tetrahydroxyethyl Ethylenediamine have different safety status in cosmetics vs industrial chemicals?
Tetrahydroxyethyl Ethylenediamine is classified GHS Danger (H302, H315, H318) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Tetrahydroxyethyl Ethylenediamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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