Tetramethyl-1-oxaspiro[4.5]dec-6-ene

INCI: TETRAMETHYL-1-OXASPIRO-6-DECENE

CAS Number
36431-72-8
Function
Fragrance (Parfum) – theaspirane-type, black tea aroma
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted for cosmetic use as fragrance ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

RIFM evaluated for genotoxicity, repeated dose, and reproductive toxicity — all within acceptable margins; theaspirane analog

⚠️
Concern Level: Moderate

Regulatory Flags

fragrance-component ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Tetramethyl-1-oxaspiro[4.5]dec-6-ene safe in cosmetics?

RIFM evaluated for genotoxicity, repeated dose, and reproductive toxicity — all within acceptable margins; theaspirane analog The EU classifies Tetramethyl-1-oxaspiro[4.5]dec-6-ene as "permitted". Safety rating: GOOD.

Is Tetramethyl-1-oxaspiro[4.5]dec-6-ene allowed in the EU?

Tetramethyl-1-oxaspiro[4.5]dec-6-ene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetramethyl-1-oxaspiro[4.5]dec-6-ene do in cosmetics?

Tetramethyl-1-oxaspiro[4.5]dec-6-ene functions as: Fragrance (Parfum) – theaspirane-type, black tea aroma. It is classified as a cosmetic ingredient in our database. CAS number: 36431-72-8.

What is the Margin of Safety for Tetramethyl-1-oxaspiro[4.5]dec-6-ene?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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