Tetrapeptide-11

INCI: TETRAPEPTIDE-11 (COMMONLY USED AS ACETYL TETRAPEPTIDE-11 UNDER THE TRADE NAME SYNIORAGE)

CAS Number
Often supplied as Acetyl Tetrapeptide-11 (CAS 928006-88-6 for the acetylated form)
Function
Skin conditioning / skin repairing — stimulates syndecan-1 expression, improving skin structure and firmness
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Better-studied than many tetrapeptides due to commercial availability as Syniorage. Supplier data supports safety at recommended levels. Independent peer-reviewed data still limited

⚠️
Concern Level: Low

Frequently Asked Questions

Is Tetrapeptide-11 safe in cosmetics?

Better-studied than many tetrapeptides due to commercial availability as Syniorage. Supplier data supports safety at recommended levels. Independent peer-reviewed data still limited The EU classifies Tetrapeptide-11 as "permitted". Safety rating: GOOD.

Is Tetrapeptide-11 allowed in the EU?

Tetrapeptide-11 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetrapeptide-11 do in cosmetics?

Tetrapeptide-11 functions as: Skin conditioning / skin repairing — stimulates syndecan-1 expression, improving skin structure and firmness. It is classified as a cosmetic ingredient in our database. CAS number: Often supplied as Acetyl Tetrapeptide-11 (CAS 928006-88-6 for the acetylated form).

What is the Margin of Safety for Tetrapeptide-11?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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