Tetrapeptide-12

INCI: TETRAPEPTIDE-12

CAS Number
Not widely published
Function
Skin conditioning — reported to support melanin metabolism / skin brightening
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Very limited published safety data. Melanogenesis-modulating claims require substantiation. Relies on peptide class safety assumptions

⚠️
Concern Level: Low

Frequently Asked Questions

Is Tetrapeptide-12 safe in cosmetics?

Very limited published safety data. Melanogenesis-modulating claims require substantiation. Relies on peptide class safety assumptions The EU classifies Tetrapeptide-12 as "permitted". Safety rating: GOOD.

Is Tetrapeptide-12 allowed in the EU?

Tetrapeptide-12 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetrapeptide-12 do in cosmetics?

Tetrapeptide-12 functions as: Skin conditioning — reported to support melanin metabolism / skin brightening. It is classified as a cosmetic ingredient in our database. CAS number: Not widely published.

What is the Margin of Safety for Tetrapeptide-12?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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