Tetrapeptide-15

INCI: TETRAPEPTIDE-15

Function
Skin conditioning, anti-sensitivity (μ-opioid receptor agonist pathway — reduces neurogenic inflammation and pain perception)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted; no FDA restriction

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Limited publicly available independent toxicological data; most data is proprietary. For COSMOS/ECOCERT compliance, verify synthetic peptide acceptance with your certifier.

⚠️
Concern Level: Low

Frequently Asked Questions

Is Tetrapeptide-15 safe in cosmetics?

Limited publicly available independent toxicological data; most data is proprietary. For COSMOS/ECOCERT compliance, verify synthetic peptide acceptance with your certifier. The EU classifies Tetrapeptide-15 as "permitted". Safety rating: GOOD.

Is Tetrapeptide-15 allowed in the EU?

Tetrapeptide-15 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetrapeptide-15 do in cosmetics?

Tetrapeptide-15 functions as: Skin conditioning, anti-sensitivity (μ-opioid receptor agonist pathway — reduces neurogenic inflammation and pain perception). It is classified as a cosmetic ingredient in our database.

What is the Margin of Safety for Tetrapeptide-15?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

📱

Is Tetrapeptide-15 in Your Products?

Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.

Try Piro Free →

Analyze Your Full Ingredient List

Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tetrapeptide-15 in your formulation.