Tetrapeptide-2

INCI: TETRAPEPTIDE-2

CAS Number
1239011-60-9 (as Acetyl Tetrapeptide-2)
Function
Skin conditioning; anti-aging; immune defense stimulation; firming; compensates for thymic factor loss
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted for cosmetic use; VCPR-reportable under MoCRA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Temperature-sensitive: process below 45°C ; sequence: Ac-Lys-Asp-Val-Tyr-OH; molecular formula C₂₆H₃₉N₅O₉

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Concern Level: Low

Frequently Asked Questions

Is Tetrapeptide-2 safe in cosmetics?

Temperature-sensitive: process below 45°C ; sequence: Ac-Lys-Asp-Val-Tyr-OH; molecular formula C₂₆H₃₉N₅O₉ The EU classifies Tetrapeptide-2 as "permitted". Safety rating: GOOD.

Is Tetrapeptide-2 allowed in the EU?

Tetrapeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tetrapeptide-2 do in cosmetics?

Tetrapeptide-2 functions as: Skin conditioning; anti-aging; immune defense stimulation; firming; compensates for thymic factor loss. It is classified as a cosmetic ingredient in our database. CAS number: 1239011-60-9 (as Acetyl Tetrapeptide-2).

What is the Margin of Safety for Tetrapeptide-2?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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