Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Tetrasodium Iminodisuccinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 0.01 mg/kg bw/day | oral | code:3544 | oral | REACH |
| LOAEL | 150 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
| LOEL | 306 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Clean, biodegradable EDTA alternative with CIR safety assessment showing NOEL of 200 mg/kg bw/d; accepted by COSMOS and ECOCERT as green chelator.
Regulatory Flags
Frequently Asked Questions
Is Tetrasodium Iminodisuccinate safe in cosmetics?
Clean, biodegradable EDTA alternative with CIR safety assessment showing NOEL of 200 mg/kg bw/d; accepted by COSMOS and ECOCERT as green chelator. The EU classifies Tetrasodium Iminodisuccinate as "permitted". Safety rating: GOOD. 7 toxicological study endpoint(s) are available in our database.
Is Tetrasodium Iminodisuccinate allowed in the EU?
Tetrasodium Iminodisuccinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrasodium Iminodisuccinate do in cosmetics?
Tetrasodium Iminodisuccinate functions as: Chelating Agent. It is classified as a cosmetic ingredient in our database. CAS number: 144538-83-0.
What is the Margin of Safety for Tetrasodium Iminodisuccinate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tetrasodium Iminodisuccinate?
The NOAEL (No Observed Adverse Effect Level) for Tetrasodium Iminodisuccinate is 200 mg/kg bw/day based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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