NOAEL Studies Antioxidant

Tocopheryl Acetate NOAEL Studies

INCI: TOCOPHERYL ACETATE

CAS: 58-95-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 5.5 mg/kg bw/day rabbit oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 6.6 mg/kg bw/day rabbit oral 63 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 47 mg/kg bw/day rat oral 21 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 83 mg/kg bw/day rat oral 480 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 125 mg/kg bw/day rat oral 90 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 10 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 833 mg/kg bw/day rat oral 480 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1000 mg/kg bw/day rat oral 20 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1600 mg/kg bw/day mouse oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 4000 mg/kg bw/day rat oral 60 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =540 mg/day Human - - study with volunteers EFSA FEEDAP - 2010 - OutputID 178 - haematology - hemopoietic - Scientific Opinion on the safety and efficacy of vitamin E as a feed additive for all animal species - doi:10.2903/j.efsa.2010.1635
EFSA NOAEL =540 mg/day Human oral - epidemiologic LONG_REF=EFSA FEEDAP (2010). Scientific Opinion on the safety and efficacy of vitamin E as a feed additive for all animal species. doi:10.2903/j.efsa.2010.1635.; TITLE=Scientific Opinion on the safety and efficacy of vitamin E as a feed additive for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2010.1635; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15614237:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a215a8d747e97a5fb6770b8a9a24aac2
ECHA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =2000 mg/kg bw/day Rat oral - chronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9e4e4b0a7c65d1b346e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/25435?documentUUID=1b5482f2-44a9-41c3-a01c-c9ebf5a4b820; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15820078:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_eb0d8dd698df47c52f8fd06571b02609
ToxValDB ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX NOEL =35.7143 mg/kg bw/day Mouse oral subchronic; 42 days subchronic LONG_REF=Indian J. Exp. Biol.29(9): 823-825 Khan,S., M.A. Khan, D. Bhatnagar, P. Yadav, and S. Sarkar Zinc Protection Against Lipid Peroxidation from Cadmium 1991; TITLE=Zinc Protection Against Lipid Peroxidation from Cadmium; AUTHOR=Khan,S., M.A. Khan, D. Bhatnagar, P. Yadav, and S. Sarkar; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=82634; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Enzyme(s): Catalase|Growth: Weight|Morphology: Organ weight in relationship to body weight|Physiology: Blood volume|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|hematology|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598178_15603493:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=79066f935e81f85a7d40f84821a44952
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier A7E6112E4N UNII - - - chemical -