Is Tocopheryl Nicotinate safe in cosmetics?
Tocopheryl Nicotinate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Tocopheryl Nicotinate
INCI: TOCOPHERYL NICOTINATE
Tocopheryl Nicotinate (CAS 16676-75-8) is a cosmetic cosmetic ingredient functioning as Antioxidant, Skin Conditioning, Skin Protecting. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 16676-75-8 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Skin Conditioning, Skin Protecting
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] pyridine-3-carboxylate
InChIKey
MSCCTZZBYHQMQJ-AZAGJHQNSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions; present in 3 cosmetic formulations in 1998 VCRP at ≤1%
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tocopheryl Nicotinate.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "slow", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "10", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": "…
vitamin
{"cas_number": "51898-34-1", "ingredient_class": "vitamin_E", "chemical_form": "ester", "derivative_type": "stabilized", "molecular_weight_Da": "535.80", "water_solubility": "insoluble", "oil_solubility": "soluble", "log_P": "11.80", "stability_to_light": "excellent", "stability_to_heat": "excellent", "stability_to_oxidation": "excellent", "stability_to_pH_acid": "excellent", "stability_to_pH_alka…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Expert Verdict
Expert safety assessment and concern-level summary for Tocopheryl Nicotinate.
Frequently Asked Questions
Is Tocopheryl Nicotinate allowed in the EU?
Tocopheryl Nicotinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tocopheryl Nicotinate do in cosmetics?
Tocopheryl Nicotinate functions as: Antioxidant, Skin Conditioning, Skin Protecting. It is classified as a cosmetic ingredient in our database. CAS number: 16676-75-8.
Compliance Tools
Check Tocopheryl Nicotinate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Tocopheryl Linoleate
Good
Same category
Antioxidant, Skin Conditioning, Skin ...
Ergocalciferol
Moderate
Same category
Skin Conditioning
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
TRACHELOSPERMUM JASMINOIDES EXTRACT
Good
Browse nearby
Skin Conditioning
TRAMETES VERSICOLOR EXTRACT
Good
Browse nearby
Hair Conditioning
TRANS, TRANS-2,4-DECADIENAL
Good
Browse nearby
Perfuming
TRANS, TRANS-NONA-2,4-DIENAL
Good
Browse nearby
Perfuming
(20S)-Protopanaxadiol
Moderate
Same EU status
Is Tocopheryl Nicotinate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tocopheryl Nicotinate in your formulation.