Is Tolnaftate safe in cosmetics?
Tolnaftate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: prohibited.
Moderate
Cosmetic Ingredient
Tolnaftate
Also known as: BRN 2752620, Carbanilic acid, N,m-dimethylthio-, O-2-naphthyl ester, Dermoxin, EINECS 219-266-6, Fungistop (+8 more)
INCI: TOLNAFTATE
Tolnaftate (CAS 2398-96-1) is a cosmetic cosmetic ingredient functioning as Antifungal agent (OTC drug in the US; not a standard cosmetic function). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2398-96-1 →
Auto-generated CPSR Part A draft with source citations
Function
Antifungal agent (OTC drug in the US; not a standard cosmetic function)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
O-naphthalen-2-yl N-methyl-N-(3-methylphenyl)carbamothioate
InChIKey
FUSNMLFNXJSCDI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Listed on the Cosmetic Ingredient Hotlist (prohibited/restricted)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tolnaftate.
Calculate MoS for your specific formulation with the MoS Calculator.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | banned | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for Tolnaftate.
Known Synonyms
BRN 2752620
Carbanilic acid, N,m-dimethylthio-, O-2-naphthyl ester
Dermoxin
EINECS 219-266-6
Fungistop
HI-Alazin
Tinavet
Tolnaftatum
UNII-06KB629TKV
Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester
N-methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide
O-2-Naphthyl m,N-dimethylthiocarbanilate
m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester
Chemical Function
Biocide
No specific technical function
Regulatory Lists
pharmaceutical
active_ingredient; Europe; Pesticides
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TOLNAFTATE
ChEMBL ID
CHEMBL83668
Max Phase
3
Adverse Event Associations
105
Frequently Asked Questions
Is Tolnaftate allowed in the EU?
Tolnaftate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tolnaftate do in cosmetics?
Tolnaftate functions as: Antifungal agent (OTC drug in the US; not a standard cosmetic function). It is classified as a cosmetic ingredient in our database. CAS number: 2398-96-1.
Is Tolnaftate used outside cosmetics?
Tolnaftate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tolnaftate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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