Triethylene Glycol Dimethacrylate (TEGDMA)
INCI: TRIETHYLENE GLYCOL DIMETHACRYLATE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Triethylene Glycol Dimethacrylate (TEGDMA). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | dermal | code:3543 | dermal | REACH |
| LOAEL | 500 mg/kg bw/day | dermal | code:3543 | dermal | REACH |
| NOAEL | 1522 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 100 mg/kg bw/day | dermal | code:3543 | dermal | REACH |
| NOAEL | 1522 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | dermal | code:3543 | dermal | REACH |
Sensitization Profile
Contact sensitization data for Triethylene Glycol Dimethacrylate (TEGDMA) based on clinical patch test studies and IFRA standards.
Source: IVDK; ESSCA
Expert Verdict
Known contact sensitizer — methacrylate allergy is increasingly reported. Residual monomer must be minimized. Cytotoxic to cells in uncured form. Not recommended for leave-on skin products. Restrict to nail/UV-cured systems with full polymerization verification
Regulatory Flags
Frequently Asked Questions
Is Triethylene Glycol Dimethacrylate (TEGDMA) safe in cosmetics?
Known contact sensitizer — methacrylate allergy is increasingly reported. Residual monomer must be minimized. Cytotoxic to cells in uncured form. Not recommended for leave-on skin products. Restrict to nail/UV-cured systems with full polymerization verification The EU classifies Triethylene Glycol Dimethacrylate (TEGDMA) as "permitted". Safety rating: MODERATE. 7 toxicological study endpoint(s) are available in our database.
Is Triethylene Glycol Dimethacrylate (TEGDMA) allowed in the EU?
Triethylene Glycol Dimethacrylate (TEGDMA) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Triethylene Glycol Dimethacrylate (TEGDMA) do in cosmetics?
Triethylene Glycol Dimethacrylate (TEGDMA) functions as: Cross-linking agent, film forming agent (primarily dental/nail applications). It is classified as a cosmetic ingredient in our database. CAS number: 109-16-0.
What is the Margin of Safety for Triethylene Glycol Dimethacrylate (TEGDMA)?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Triethylene Glycol Dimethacrylate (TEGDMA)?
The NOAEL (No Observed Adverse Effect Level) for Triethylene Glycol Dimethacrylate (TEGDMA) is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 7 study endpoints are available. Source: REACH.
Compliance Tools
Check Triethylene Glycol Dimethacrylate (TEGDMA) compliance across multiple jurisdictions:
Related Ingredients
Is Triethylene Glycol Dimethacrylate (TEGDMA) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Triethylene Glycol Dimethacrylate (TEGDMA) in your formulation.