Triethylenetetramine HCl

INCI: TRIETHYLENETETRAMINE HCL

CAS Number
112-24-3 (free base triethylenetetramine); HCl salt CAS varies
Function
Chelating agent, hair conditioning agent (polyamine capable of binding metal ions)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; note that the free base (trientine) is an FDA-approved drug for Wilson's disease โ€” dual-use substance

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Free base is corrosive (Skin Corr. 1B); the HCl salt is less aggressive but still irritating. pH must be carefully controlled in formulation. Oral form is a prescription drug (chelator) โ€” systemic effects include copper/zinc depletion. Avoid use near mucous membranes at elevated concentrations

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Concern Level: Moderate

Frequently Asked Questions

Is Triethylenetetramine HCl safe in cosmetics?

Free base is corrosive (Skin Corr. 1B); the HCl salt is less aggressive but still irritating. pH must be carefully controlled in formulation. Oral form is a prescription drug (chelator) โ€” systemic effects include copper/zinc depletion. Avoid use near mucous membranes at elevated concentrations The EU classifies Triethylenetetramine HCl as "permitted". Safety rating: MODERATE.

Is Triethylenetetramine HCl allowed in the EU?

Triethylenetetramine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Triethylenetetramine HCl do in cosmetics?

Triethylenetetramine HCl functions as: Chelating agent, hair conditioning agent (polyamine capable of binding metal ions). It is classified as a cosmetic ingredient in our database. CAS number: 112-24-3 (free base triethylenetetramine); HCl salt CAS varies.

What is the Margin of Safety for Triethylenetetramine HCl?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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